Biodegradable polymer hydrogel?based tissue adhesives: A review

Tissue-adhesive materials are emerging biomaterials with potential applications in wound healing patches, tissue sealants, and haemostat materials. Tissue adhesives based on synthetic polymers generally have good adhesion but not biodegradable. However, the long-term presence of non-biodegradable body can cause secondary harm to patient. An ideal adhesive should meet following requirements: adhesiveness, biodegradability, low cytotoxicity, minimal inflammatory response. Natural inherent biodegradation biocompatibility show great potentials biomedical engineering, development natural has become a hot topic science. This review systematically summarises latest progresses biodegradable polymers, such as chitosan, hyaluronic acid, alginate, gelatin, dextran, cellulose. Methods for preparing polymer summarised their advantages disadvantages discussed. Finally, trends future direction